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Target
Prostacyclin receptor
Ligand
BDBM50163051
Substrate
n/a
Meas. Tech.
ChEMBL_1570587 (CHEMBL3794955)
IC50
740±n/a nM
Citation
 Hayashi, R; Sakagami, H; Koiwa, M; Ito, H; Miyamoto, M; Isogaya, M Piperidine derivatives as nonprostanoid IP receptor agonists. Bioorg Med Chem Lett 26:2360-4 (2016) [PubMed]  Article 
Target
Name:
Prostacyclin receptor
Synonyms:
PGI receptor | PI2R_HUMAN | PRIPR | PTGIR | Prostacyclin (IP) Receptor | Prostacyclin receptor | Prostaglandin I | Prostaglandin I2 | Prostaglandin I2 receptor | Prostanoid IP receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40968.22
Organism:
Homo sapiens (Human)
Description:
The membranes prepared from human platelet were used in binding assay.
Residue:
386
Sequence:
MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATDLLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLALSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPGGAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLILLALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVFQRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPLPPTQQSSGSAVGTSSKAEASVACSLC
  
Inhibitor
Name:
BDBM50163051
Synonyms:
CHEMBL3793336
Type:
Small organic molecule
Emp. Form.:
C23H20ClNO4
Mol. Mass.:
409.862
SMILES:
OC(=O)COc1ccc(CCN(C(=O)c2ccccc2)c2ccc(Cl)cc2)cc1
Structure:
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