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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM50165383
Substrate
n/a
Meas. Tech.
ChEMBL_1573233 (CHEMBL3803473)
EC50
2090±n/a nM
Citation
 Lescop, C; Müller, C; Mathys, B; Birker, M; de Kanter, R; Kohl, C; Hess, P; Nayler, O; Rey, M; Sieber, P; Steiner, B; Weller, T; Bolli, MH Novel S1P1 receptor agonists - Part 4: Alkylaminomethyl substituted aryl head groups. Eur J Med Chem 116:222-238 (2016) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM50165383
Synonyms:
CHEMBL3800203
Type:
Small organic molecule
Emp. Form.:
C24H30N4O5
Mol. Mass.:
454.5188
SMILES:
CCc1cc(cc(C)c1OC[C@@H](O)CNC(=O)CO)-c1noc(n1)-c1ccc(CNC)cc1 |r|
Structure:
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