Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50168104
Substrate
n/a
Meas. Tech.
ChEMBL_1575929 (CHEMBL3802552)
Ki
6.2±n/a nM
Citation
 Squarcialupi, L; Falsini, M; Catarzi, D; Varano, F; Betti, M; Varani, K; Vincenzi, F; Dal Ben, D; Lambertucci, C; Volpini, R; Colotta, V Exploring the 2- and 5-positions of the pyrazolo[4,3-d]pyrimidin-7-amino scaffold to target human A1 and A2A adenosine receptors. Bioorg Med Chem 24:2794-808 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50168104
Synonyms:
CHEMBL3799848
Type:
Small organic molecule
Emp. Form.:
C17H14ClN5O
Mol. Mass.:
339.779
SMILES:
Cc1ccc(o1)-c1nc(N)c2nn(Cc3ccccc3Cl)cc2n1
Structure:
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