Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50170036
Substrate
n/a
Meas. Tech.
ChEMBL_1576906 (CHEMBL3806615)
Ki
1.4±n/a nM
Citation
 Cao, X; Chen, Y; Zhang, Y; Lan, Y; Zhang, J; Xu, X; Qiu, Y; Zhao, S; Liu, X; Liu, BF; Zhang, G Synthesis and Biological Evaluation of Novels1 Receptor Ligands for Treating Neuropathic Pain: 6-Hydroxypyridazinones. J Med Chem 59:2942-61 (2016) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50170036
Synonyms:
CHEMBL3805396
Type:
Small organic molecule
Emp. Form.:
C18H21Cl2N3O2
Mol. Mass.:
382.284
SMILES:
Clc1ccc(cc1Cl)-n1nc(OCCCN2CCCCC2)ccc1=O
Structure:
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