Reaction Details Report a problem with these data
Target
Ovarian cancer G-protein coupled receptor 1
Ligand
BDBM50175290
Substrate
n/a
Meas. Tech.
ChEMBL_1581088 (CHEMBL3813386)
pH
7.2±n/a
IC50
>10000±n/a nM
Comments
extracted
Citation
 Fukuda, H; Ito, S; Watari, K; Mogi, C; Arisawa, M; Okajima, F; Kurose, H; Shuto, S Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction. ACS Med Chem Lett 7:493-7 (2016) [PubMed]  Article 
Target
Name:
Ovarian cancer G-protein coupled receptor 1
Synonyms:
G-protein coupled receptor 68 | GPR12A | GPR68 | OGR-1 | OGR1 | OGR1_HUMAN | Ovarian cancer G-protein coupled receptor 1 | Sphingosylphosphorylcholine receptor
Type:
PROTEIN
Mol. Mass.:
41085.24
Organism:
Homo sapiens (Human)
Description:
ChEMBL_115877
Residue:
365
Sequence:
MGNITADNSSMSCTIDHTIHQTLAPVVYVTVLVVGFPANCLSLYFGYLQIKARNELGVYLCNLTVADLFYICSLPFWLQYVLQHDNWSHGDLSCQVCGILLYENIYISVGFLCCISVDRYLAVAHPFRFHQFRTLKAAVGVSVVIWAKELLTSIYFLMHEEVIEDENQHRVCFEHYPIQAWQRAINYYRFLVGFLFPICLLLASYQGILRAVRRSHGTQKSRKDQIQRLVLSTVVIFLACFLPYHVLLLVRSVWEASCDFAKGVFNAYHFSLLLTSFNCVADPVLYCFVSETTHRDLARLRGACLAFLTCSRTGRAREAYPLGAPEASGKSGAQGEEPELLTKLHPAFQTPNSPGSGGFPTGRLA
  
Inhibitor
Name:
BDBM50175290
Synonyms:
CHEMBL3810385
Type:
Small organic molecule
Emp. Form.:
C31H37N5
Mol. Mass.:
479.659
SMILES:
CCc1nc2c(C)cc(C)nc2n1Cc1ccc2Nc3ccc(CN4CCCCC4)cc3CCc2c1
Structure:
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