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Target
Apelin receptor
Ligand
BDBM50183373
Substrate
n/a
Meas. Tech.
ChEMBL_1586257 (CHEMBL3820075)
EC50
>30000±n/a nM
Citation
 Narayanan, S; Maitra, R; Deschamps, JR; Bortoff, K; Thomas, JB; Zhang, Y; Warner, K; Vasukuttan, V; Decker, A; Runyon, SP Discovery of a novel small molecule agonist scaffold for the APJ receptor. Bioorg Med Chem 24:3758-70 (2016) [PubMed]  Article 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM50183373
Synonyms:
CHEMBL3818388
Type:
Small organic molecule
Emp. Form.:
C26H28FN3O5
Mol. Mass.:
481.516
SMILES:
COc1cccc(OC)c1-c1cc(C(=O)N[C@@H](C2CCCCC2)C(O)=O)n(n1)-c1ccc(F)cc1 |r|
Structure:
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