Reaction Details Report a problem with these data
Target
Protein-S-isoprenylcysteine O-methyltransferase
Ligand
BDBM50183409
Substrate
n/a
Meas. Tech.
ChEMBL_1586733 (CHEMBL3825050)
Ki
2900±n/a nM
Citation
 Butler, KV; Bohn, K; Hrycyna, CA; Jin, J Non-Substrate Based, Small Molecule Inhibitors of the Human Isoprenylcysteine Carboxyl Methyltransferase. Medchemcomm 7:1016-1021 (2016) [PubMed]  Article 
Target
Name:
Protein-S-isoprenylcysteine O-methyltransferase
Synonyms:
ICMT | ICMT_HUMAN | Isoprenylcysteine carboxyl methyltransferase | PCCMT
Type:
PROTEIN
Mol. Mass.:
31943.26
Organism:
Homo sapiens (Human)
Description:
ChEMBL_956034
Residue:
284
Sequence:
MAGCAARAPPGSEARLSLATFLLGASVLALPLLTRAGLQGRTGLALYVAGLNALLLLLYRPPRYQIAIRACFLGFVFGCGTLLSFSQSSWSHFGWYMCSLSLFHYSEYLVTAVNNPKSLSLDSFLLNHSLEYTVAALSSWLEFTLENIFWPELKQITWLSVTGLLMVVFGECLRKAAMFTAGSNFNHVVQNEKSDTHTLVTSGVYAWFRHPSYVGWFYWSIGTQVMLCNPICGVSYALTVWRFFRDRTEEEEISLIHFFGEEYLEYKKRVPTGLPFIKGVKVDL
  
Inhibitor
Name:
BDBM50183409
Synonyms:
CHEMBL3822531
Type:
Small organic molecule
Emp. Form.:
C20H18OS
Mol. Mass.:
306.421
SMILES:
[#6]-1-[#6]\[#6](-[#6]-[#6]-[#8]-1)=[#6](\c1cccs1)-c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: