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Target
Hypoxia-inducible factor 1-alpha
Ligand
BDBM50190660
Substrate
n/a
Meas. Tech.
ChEMBL_1612400 (CHEMBL3854200)
IC50
35200±n/a nM
Citation
 Goey, AK; Chau, CH; Sissung, TM; Cook, KM; Venzon, DJ; Castro, A; Ransom, TR; Henrich, CJ; McKee, TC; McMahon, JB; Grkovic, T; Cadelis, MM; Copp, BR; Gustafson, KR; Figg, WD Screening and Biological Effects of Marine Pyrroloiminoquinone Alkaloids: Potential Inhibitors of the HIF-1a/p300 Interaction. J Nat Prod 79:1267-75 (2016) [PubMed]  Article 
Target
Name:
Hypoxia-inducible factor 1-alpha
Synonyms:
BHLHE78 | HIF-1-alpha | HIF-1-alpha, HIF-2-alpha | HIF1A | HIF1A_HUMAN | Hypoxia inducible factors | Hypoxia-inducible factor 1 alpha | Hypoxia-inducible factor 1-alpha | MOP1 | PASD8 | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A
Type:
Protein
Mol. Mass.:
92647.24
Organism:
Homo sapiens (Human)
Description:
Q16665
Residue:
826
Sequence:
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
  
Inhibitor
Name:
BDBM50190660
Synonyms:
CHEMBL3920971
Type:
Small organic molecule
Emp. Form.:
C18H15Br2N3O2
Mol. Mass.:
465.139
SMILES:
O[C@H]1C(Br)=C[C@@]2(CCNC3=C2C2=NCCc4c[nH]c(c24)C3=O)C=C1Br |r,wU:5.4,wD:1.0,c:3,9,26,t:12,(13.65,-19.56,;13.66,-18.02,;15,-17.26,;16.39,-18.07,;15.01,-15.71,;13.68,-14.94,;15.02,-14.18,;15.03,-12.65,;13.7,-11.71,;12.36,-12.63,;12.36,-14.17,;11.05,-14.94,;11.05,-16.46,;9.72,-17.22,;8.25,-16.33,;8.24,-14.65,;7.33,-13.4,;8.2,-12.02,;9.71,-12.62,;9.71,-14.17,;11.05,-11.85,;11.05,-10.31,;12.34,-15.7,;12.34,-17.23,;11.01,-17.99,)|
Structure:
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