Reaction Details Report a problem with these data
Target
Prostaglandin E synthase
Ligand
BDBM50197516
Substrate
n/a
Meas. Tech.
ChEMBL_1619471 (CHEMBL3861640)
IC50
>10000±n/a nM
Citation
 Park, EB; Kim, KJ; Jeong, HR; Lee, JK; Kim, HJ; Lee, HH; Lim, JW; Shin, JS; Koeberle, A; Werz, O; Lee, KT; Lee, JY Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents. Bioorg Med Chem Lett 26:5193-5197 (2016) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
5.3.99.3 | Microsomal prostaglandin E synthase 1 | PTGES_MOUSE | Pges | Prostaglandin E synthase | Ptges | mPGES-1
Type:
PROTEIN
Mol. Mass.:
17293.88
Organism:
Mus musculus
Description:
ChEMBL_104562
Residue:
153
Sequence:
MPSPGLVMESGQVLPAFLLCSTLLVIKMYAVAVITGQMRLRKKAFANPEDALKRGGLQYYRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWIHFLVVLTGRVVHTVAYLGKLNPRLRSGAYVLAQFSCFSMALQILWEVAHHL
  
Inhibitor
Name:
BDBM50197516
Synonyms:
CHEMBL3961576
Type:
Small organic molecule
Emp. Form.:
C21H20N2O6S
Mol. Mass.:
428.458
SMILES:
COc1ccc(cc1)S(=O)(=O)NN(C(=O)Oc1ccccc1OC)c1ccccc1
Structure:
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