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Target
Complement factor D
Ligand
BDBM50201564
Substrate
n/a
Meas. Tech.
ChEMBL_1623110 (CHEMBL3865462)
IC50
27±n/a nM
Citation
 Yang, CY; Phillips, JG; Stuckey, JA; Bai, L; Sun, H; Delproposto, J; Brown, WC; Chinnaswamy, K Buried Hydrogen Bond Interactions Contribute to the High Potency of Complement Factor D Inhibitors. ACS Med Chem Lett 7:1092-1096 (2016) [PubMed]  Article 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM50201564
Synonyms:
CHEMBL3890777
Type:
Small organic molecule
Emp. Form.:
C18H16BrN7O3S
Mol. Mass.:
490.334
SMILES:
NC(=O)c1nn(CC(=O)N2CCS[C@H]2C(=O)Nc2cccc(Br)n2)c2ncccc12 |r|
Structure:
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