Reaction Details Report a problem with these data
Target
Cell division protein FtsZ
Ligand
BDBM50320891
Substrate
n/a
Meas. Tech.
ChEMBL_1623447 (CHEMBL3865859)
IC50
77400±n/a nM
Citation
 Haranahalli, K; Tong, S; Ojima, I Recent advances in the discovery and development of antibacterial agents targeting the cell-division protein FtsZ. Bioorg Med Chem 24:6354-6369 (2016) [PubMed]  Article 
Target
Name:
Cell division protein FtsZ
Synonyms:
FTSZ_STAAU | ftsZ
Type:
Protein
Mol. Mass.:
41023.36
Organism:
Staphylococcus aureus
Description:
P0A031
Residue:
390
Sequence:
MLEFEQGFNHLATLKVIGVGGGGNNAVNRMIDHGMNNVEFIAINTDGQALNLSKAESKIQIGEKLTRGLGAGANPEIGKKAAEESREQIEDAIQGADMVFVTSGMGGGTGTGAAPVVAKIAKEMGALTVGVVTRPFSFEGRKRQTQAAAGVEAMKAAVDTLIVIPNDRLLDIVDKSTPMMEAFKEADNVLRQGVQGISDLIAVSGEVNLDFADVKTIMSNQGSALMGIGVSSGENRAVEAAKKAISSPLLETSIVGAQGVLMNITGGESLSLFEAQEAADIVQDAADEDVNMIFGTVINPELQDEIVVTVIATGFDDKPTSHGRKSGSTGFGTSVNTSSNATSKDESFTSNSSNAQATDSVSERTHTTKEDDIPSFIRNREERRSRRTRR
  
Inhibitor
Name:
BDBM50320891
Synonyms:
9-O-[3-(4-Chloro-phenoxyl)propyl]-berberine bromide | CHEMBL1164137
Type:
Small organic molecule
Emp. Form.:
C28H25ClNO5
Mol. Mass.:
490.954
SMILES:
COc1ccc2cc3-c4cc5OCOc5cc4CC[n+]3cc2c1OCCCOc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: