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Target
Histamine H1 receptor
Ligand
BDBM50202728
Substrate
n/a
Meas. Tech.
ChEMBL_1624854 (CHEMBL3867266)
Ki
6.3±n/a nM
Citation
 Kuhne, S; Kooistra, AJ; Bosma, R; Bortolato, A; Wijtmans, M; Vischer, HF; Mason, JS; de Graaf, C; de Esch, IJ; Leurs, R Identification of Ligand Binding Hot Spots of the Histamine H J Med Chem 59:9047-9061 (2016) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Homo sapiens (Human)
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50202728
Synonyms:
CHEMBL3910939
Type:
Small organic molecule
Emp. Form.:
C22H24ClNO5
Mol. Mass.:
417.883
SMILES:
OC(=O)\C=C\C(O)=O.Clc1ccc(Cc2ccccc2OC2CCNCC2)cc1
Structure:
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