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Target
Alpha-1B adrenergic receptor
Ligand
BDBM50198338
Substrate
n/a
Meas. Tech.
ChEMBL_1625179 (CHEMBL3867648)
Ki
13±n/a nM
Citation
 Silva, RO; de Oliveira, AS; Nunes Lemes, LF; de Camargo Nascente, L; Coelho do Nascimento Nogueira, P; Silveira, ER; Brand, GD; Vistoli, G; Cilia, A; Poggesi, E; Buccioni, M; Marucci, G; Bolognesi, ML; Romeiro, LAS Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists ofa1-adrenoceptor. Eur J Med Chem 122:601-610 (2016) [PubMed]  Article 
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADA1B_HUMAN | ADRA1B | Adrenergic alpha1B | Adrenergic receptor | Adrenergic receptor alpha | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha-1B adrenergic receptor
Type:
Enzyme
Mol. Mass.:
56862.13
Organism:
Homo sapiens (Human)
Description:
P35368
Residue:
520
Sequence:
MNPDLDTGHNTSAPAHWGELKNANFTGPNQTSSNSTLPQLDITRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAMADLLLSFTVLPFSAALEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFVRILGCQCRGRGRRRRRRRRRLGGCAYTYRPWTRGGSLERSQSRKDSLDDSGSCLSGSQRTLPSASPSPGYLGRGAPPPVELCAFPEWKAPGALLSLPAPEPPGRRGRHDSGPLFTFKLLTEPESPGTDGGASNGGCEAAADVANGQPGFKSNMPLAPGQF
  
Inhibitor
Name:
BDBM50198338
Synonyms:
CHEMBL3938038
Type:
Small organic molecule
Emp. Form.:
C22H28N2O3
Mol. Mass.:
368.4693
SMILES:
CC(C)Oc1ccccc1N1CCN(CCc2ccc3OCOc3c2)CC1
Structure:
Search PDB for entries with ligand similarity: