Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50204010
Substrate
n/a
Meas. Tech.
ChEMBL_1625978 (CHEMBL3868447)
EC50
<300±n/a nM
Citation
 Chen, C; Li, H; Long, YQ GPR40 agonists for the treatment of type 2 diabetes mellitus: The biological characteristics and the chemical space. Bioorg Med Chem Lett 26:5603-5612 (2016) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50204010
Synonyms:
CHEMBL3928769
Type:
Small organic molecule
Emp. Form.:
C31H33NO6
Mol. Mass.:
515.5968
SMILES:
Cc1cc(OC[C@H]2COC(C)(C)O2)cc(C)c1-c1cccc(COc2ccc(cc2)-c2cc(O)no2)c1C |r,wU:6.5,(33.28,-31.78,;31.94,-32.55,;30.61,-31.78,;29.27,-32.55,;27.94,-31.78,;26.61,-32.55,;25.27,-31.79,;23.86,-32.41,;22.83,-31.27,;23.59,-29.93,;22.49,-28.83,;23.99,-28.43,;25.1,-30.25,;29.28,-34.1,;30.61,-34.86,;30.62,-36.4,;31.94,-34.09,;33.27,-34.86,;33.27,-36.4,;34.6,-37.17,;35.94,-36.4,;35.93,-34.85,;37.27,-34.08,;38.6,-34.84,;39.93,-34.07,;41.27,-34.84,;42.6,-34.07,;42.59,-32.52,;41.24,-31.76,;39.92,-32.54,;43.92,-31.74,;45.33,-32.36,;46.36,-31.21,;47.89,-31.36,;45.58,-29.88,;44.08,-30.21,;34.6,-34.09,;34.59,-32.55,)|
Structure:
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