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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50204225
Substrate
n/a
Meas. Tech.
ChEMBL_1626987 (CHEMBL3869508)
EC50
1.3±n/a nM
Citation
 Fang, Y; Yang, Z; Gundeti, S; Lee, J; Park, H Novel 5-nitropyrimidine derivatives bearing endo-azabicyclic alcohols/amines as potent GPR119 agonists. Bioorg Med Chem 25:254-260 (2017) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50204225
Synonyms:
CHEMBL3912040
Type:
Small organic molecule
Emp. Form.:
C23H26FN7O4
Mol. Mass.:
483.4954
SMILES:
CC(C)(C)OC(=O)N1[C@@H]2CC[C@@H]1CC(C2)Nc1ncnc(Nc2ccc(cc2F)C#N)c1[N+]([O-])=O |r,@@:13,THB:15:13:7:9.10,5:7:9.10:14.13.12|
Structure:
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