Reaction Details
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Calcium release-activated calcium channel protein 1
Ligand
BDBM50204537
Substrate
n/a
Meas. Tech.
ChEMBL_1627486 (CHEMBL3870007)
IC50
57000±n/a nM
Citation
Azimi, I; Flanagan, JU; Stevenson, RJ; Inserra, M; Vetter, I; Monteith, GR; Denny, WA Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca Bioorg Med Chem 25:440-449 (2017) [PubMed] Article More Info.:
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
Inhibitor
Name:
BDBM50204537
Synonyms:
CHEMBL100350
Type:
Small organic molecule
Emp. Form.:
C18H10ClF6N3O
Mol. Mass.:
433.735
SMILES:
FC(F)(F)c1cc(n(n1)-c1ccc(NC(=O)c2ccc(Cl)cc2)cc1)C(F)(F)F
Structure:
