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Target
Calcium release-activated calcium channel protein 1
Ligand
BDBM50204543
Substrate
n/a
Meas. Tech.
ChEMBL_1627486 (CHEMBL3870007)
IC50
75000±n/a nM
Citation
 Azimi, I; Flanagan, JU; Stevenson, RJ; Inserra, M; Vetter, I; Monteith, GR; Denny, WA Evaluation of known and novel inhibitors of Orai1-mediated store operated Ca Bioorg Med Chem 25:440-449 (2017) [PubMed]  Article 
Target
Name:
Calcium release-activated calcium channel protein 1
Synonyms:
CRACM1 | CRCM1_HUMAN | Calcium channel (VER) | Calcium release-activated calcium channel | Calcium release-activated calcium channel protein 1 | ORAI1 | Protein orai-1 | TMEM142A | Transmembrane protein 142A
Type:
Protein
Mol. Mass.:
32676.63
Organism:
Homo sapiens (Human)
Description:
Q96D31
Residue:
301
Sequence:
MHPEPAPPPSRSSPELPPSGGSTTSGSRRSRRRSGDGEPPGAPPPPPSAVTYPDWIGQSYSEVMSLNEHSMQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLDADHDYPPGLLIAFSACTTVLVAVHLFALMISTCILPNIEAVSNVHNLNSVKESPHERMHRHIELAWAFSTVIGTLLFLAEVVLLCWVKFLPLKKQPGQPRPTSKPPASGAAANVSTSGITPGQAAAIASTTIMVPFGLIFIVFAVHFYRSLVSHKTDRQFQELNELAEFARLQDQLDHRGDHPLTPGSHYA
  
Inhibitor
Name:
BDBM50204543
Synonyms:
CHEMBL1545070
Type:
Small organic molecule
Emp. Form.:
C25H32N2O3
Mol. Mass.:
408.5332
SMILES:
COc1ccc(OCC(=O)N2CCN(CC2)C2CCC(CC2)c2ccccc2)cc1 |(-12.98,-11.57,;-12.98,-10.03,;-11.64,-9.26,;-10.31,-10.03,;-8.98,-9.26,;-8.98,-7.72,;-7.64,-6.95,;-7.64,-5.41,;-6.31,-4.64,;-4.97,-5.41,;-6.31,-3.1,;-4.97,-2.33,;-4.97,-.79,;-6.31,-.02,;-7.64,-.79,;-7.64,-2.33,;-6.31,1.52,;-7.64,2.29,;-7.64,3.83,;-6.31,4.6,;-4.97,3.83,;-4.97,2.29,;-6.31,6.14,;-7.64,6.91,;-7.64,8.45,;-6.31,9.22,;-4.97,8.45,;-4.97,6.91,;-10.31,-6.95,;-11.64,-7.72,)|
Structure:
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