Reaction Details Report a problem with these data
Target
Thioredoxin reductase
Ligand
BDBM50206463
Substrate
n/a
Meas. Tech.
ChEMBL_1629022 (CHEMBL3871648)
Ki
27000±n/a nM
Citation
 Ansari, MF; Siddiqui, SM; Ahmad, K; Avecilla, F; Dharavath, S; Gourinath, S; Azam, A Synthesis, antiamoebic and molecular docking studies of furan-thiazolidinone hybrids. Eur J Med Chem 124:393-406 (2016) [PubMed]  Article 
Target
Name:
Thioredoxin reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
33740.27
Organism:
Entamoeba histolytica
Description:
ChEMBL_116971
Residue:
314
Sequence:
MSNIHDVVIIGSGPAAHTAAIYLGRSSLKPVMYEGFMAGGVAAGGQLTTTTIIENFPGFPNGIDGNELMMNMRTQSEKYGTTIITETIDHVDFSTQPFKLFTEEGKEVLTKSVIIATGATAKRMHVPGEDKYWQNGVSACAICDGAVPIFRNKVLMVVGGGDAAMEEALHLTKYGSKVIILHRRDAFRASKTMQERVLNHPKIEVIWNSELVELEGDGDLLNGAKIHNLVSGEYKVVPVAGLFYAIGHSPNSKFLGGQVKTADDGYILTEGPKTSVDGVFACGDVCDRVYRQAIVAAGSGCMAALSCEKWLQTH
  
Inhibitor
Name:
BDBM50206463
Synonyms:
CHEMBL3897298
Type:
Small organic molecule
Emp. Form.:
C22H16N2O4S
Mol. Mass.:
404.438
SMILES:
O=C1N(Cc2ccco2)\C(S\C1=C/c1ccc2OCOc2c1)=N\c1ccccc1
Structure:
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