Reaction Details Report a problem with these data
Target
Adenosine receptor A2b
Ligand
BDBM50211078
Substrate
n/a
Meas. Tech.
ChEMBL_1636007 (CHEMBL3878905)
IC50
452±n/a nM
Citation
 Varano, F; Catarzi, D; Vincenzi, F; Betti, M; Falsini, M; Ravani, A; Borea, PA; Colotta, V; Varani, K Design, Synthesis, and Pharmacological Characterization of 2-(2-Furanyl)thiazolo[5,4-d]pyrimidine-5,7-diamine Derivatives: New Highly Potent A J Med Chem 59:10564-10576 (2016) [PubMed]  Article 
Target
Name:
Adenosine receptor A2b
Synonyms:
AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36341.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
332
Sequence:
MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFAIPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYLLCQADVKSGNGQAGVQPALGVGL
  
Inhibitor
Name:
BDBM50211078
Synonyms:
CHEMBL3904408
Type:
Small organic molecule
Emp. Form.:
C17H15N5O2S
Mol. Mass.:
353.398
SMILES:
COc1cccc(CNc2nc(N)c3nc(sc3n2)-c2ccco2)c1
Structure:
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