Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM50212647
Substrate
n/a
Meas. Tech.
ChEMBL_63970 (CHEMBL677438)
KON
5.600000 M-1s-1
Citation
  TBA Bioorg Med Chem Lett 3:2295-2298 (1993)   
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50212647
Synonyms:
CHEMBL75236
Type:
Small organic molecule
Emp. Form.:
C20H20N2O5
Mol. Mass.:
368.3832
SMILES:
CC[C@@H]1[C@H](Oc2ccc(cc2)C(O)=O)N(C(=O)NCc2ccccc2)C1=O
Structure:
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