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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50228478
Substrate
n/a
Meas. Tech.
ChEMBL_28190 (CHEMBL639306)
IC50
<13300±n/a nM
Citation
 Gammill, RB; Bell, FP; Bell, LT; Bisaha, SN; Wilson, GJ Antiatherosclerotic agents. A structurally novel bivalent inhibitor of acylCoA:cholesterol O-acyltransferase with systemic activity. J Med Chem 33:2685-7 (1990) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50228478
Synonyms:
CHEMBL328228
Type:
Small organic molecule
Emp. Form.:
C40H42F2N2O10
Mol. Mass.:
748.7657
SMILES:
COc1c2occ(F)c2c(OC)c2c1oc(CN1CCC(CCC3CCN(Cc4cc(=O)c5c(OC)c6c(F)coc6c(OC)c5o4)CC3)CC1)cc2=O
Structure:
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