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Target
Carbonic anhydrase 2
Ligand
BDBM10861
Substrate
n/a
Meas. Tech.
ChEBML_1644986
Ki
37±n/a nM
Citation
 Eldehna, WM; Al-Ansary, GH; Bua, S; Nocentini, A; Gratteri, P; Altoukhy, A; Ghabbour, H; Ahmed, HY; Supuran, CT Novel indolin-2-one-based sulfonamides as carbonic anhydrase inhibitors: Synthesis, in vitro biological evaluation against carbonic anhydrases isoforms I, II, IV and VII and molecular docking studies. Eur J Med Chem 127:521-530 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM10861
Synonyms:
4-(2-aminoethyl)benzene-1-sulfonamide | CHEMBL7087 | aromatic sulfonamide compound 7 | aromatic/heteroaromatic sulfonamide 6
Type:
Small organic molecule
Emp. Form.:
C8H12N2O2S
Mol. Mass.:
200.258
SMILES:
NCCc1ccc(cc1)S(N)(=O)=O
Structure:
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