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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50232621
Substrate
n/a
Meas. Tech.
ChEMBL_1648272 (CHEMBL3997328)
EC50
0.200000±n/a nM
Citation
 Zhu, C; Wang, L; Zhu, Y; Guo, ZZ; Liu, P; Hu, Z; Szewczyk, JW; Kang, L; Chicchi, G; Ehrhardt, A; Woods, A; Seo, T; Woods, M; van Heek, M; Dingley, KH; Pang, J; Salituro, GM; Powell, J; Terebetski, JL; Hornak, V; Campeau, LC; Orr, RK; Ujjainwalla, F; Miller, M; Stamford, A; Wood, HB; Kowalski, T; Nargund, RP; Edmondson, SD Discovery of phenyl acetamides as potent and selective GPR119 agonists. Bioorg Med Chem Lett 27:1124-1128 (2017) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50232621
Synonyms:
CHEMBL4093284
Type:
Small organic molecule
Emp. Form.:
C27H34F2N4O3
Mol. Mass.:
500.5807
SMILES:
COCc1cnc(nc1)N1CCC(CC1)[C@H]1C[C@H]1CCOc1cc(F)c(CC(=O)N2CCC2)c(F)c1 |r|
Structure:
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