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Target
Tyrosine-protein kinase SYK
Ligand
BDBM50237233
Substrate
n/a
Meas. Tech.
ChEMBL_1660848 (CHEMBL4010460)
IC50
47±n/a nM
Citation
 Huang, Y; Zhang, Y; Fan, K; Dong, G; Li, B; Zhang, W; Li, J; Sheng, C Discovery of new Syk inhibitors through structure-based virtual screening. Bioorg Med Chem Lett 27:1776-1779 (2017) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50237233
Synonyms:
CHEMBL4104392
Type:
Small organic molecule
Emp. Form.:
C25H24N6O5S
Mol. Mass.:
520.56
SMILES:
COc1ccc(Nc2nc(nc3scnc23)N2CC[C@@H](C2)NC(=O)c2ccc(cc2)C(O)=O)cc1OC |r|
Structure:
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