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Target
Protein arginine N-methyltransferase 3
Ligand
BDBM50238541
Substrate
n/a
Meas. Tech.
ChEMBL_1663867 (CHEMBL4013548)
IC50
>100000±n/a nM
Citation
 Mao, R; Shao, J; Zhu, K; Zhang, Y; Ding, H; Zhang, C; Shi, Z; Jiang, H; Sun, D; Duan, W; Luo, C Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization. J Med Chem 60:6289-6304 (2017) [PubMed]  Article 
Target
Name:
Protein arginine N-methyltransferase 3
Synonyms:
2.1.1.- | ANM3_HUMAN | HRMT1L3 | Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3 | PRMT3 | Protein arginine N-methyltransferase 3
Type:
PROTEIN
Mol. Mass.:
59886.87
Organism:
Homo sapiens
Description:
ChEMBL_101368
Residue:
531
Sequence:
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
  
Inhibitor
Name:
BDBM50238541
Synonyms:
CHEMBL4092336
Type:
Small organic molecule
Emp. Form.:
C18H17N3O4S
Mol. Mass.:
371.41
SMILES:
COC(=O)c1ccccc1NC(=O)CSc1nc2cc(OC)ccc2[nH]1
Structure:
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