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Target
Casein kinase I isoform epsilon
Ligand
BDBM274532
Substrate
n/a
Meas. Tech.
Kinase Assay
pH
7.4±n/a
Temperature
298.15±n/a K
IC50
0.484±n/a nM
Comments
extracted
Citation
 Velaparthi, U; Darne, CP; Dodd, DS; Sampognaro, AJ; Wittman, MD; Kumaravel, S; Mullick, D; Liu, P; Rachamreddy, CR Substituted imidazoles as casein kinase 1 D/E inhibitors US Patent  US9556179 Publication Date 1/31/2017 
Target
Name:
Casein kinase I isoform epsilon
Synonyms:
Axin-1/Casein kinase I epsilon | CKI-epsilon | CKIe | CSNK1E | Casein kinase 1 epsilon (CK1Ɛ) | Casein kinase I epsilon | Casein kinase I isoform epsilon (CK1 epsilon) | Casein kinase I isoform epsilon (CK1E) | Casein kinase I isoform epsilon (CK1epsilon) | KC1E_HUMAN
Type:
Protein
Mol. Mass.:
47340.25
Organism:
Homo sapiens (Human)
Description:
P49674
Residue:
416
Sequence:
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
  
Inhibitor
Name:
BDBM274532
Synonyms:
N-(6-(4-(4-fluorophenyl)-1- (1-(3,3,3-trifluoropropanoyl) piperidin-4-yl)-1H- imidazol-5-yl)imidazo [1,2-b]pyridazin- 2-yl)-4-methyl-2- (pyridin-3-yl)thiazole- 5-carboxamide | US9556179, Compound 102
Type:
Small organic molecule
Emp. Form.:
C33H27F4N9O2S
Mol. Mass.:
689.685
SMILES:
Cc1nc(sc1C(=O)Nc1cn2nc(ccc2n1)-c1c(ncn1C1CCN(CC1)C(=O)CC(F)(F)F)-c1ccc(F)cc1)-c1cccnc1
Structure:
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