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Target
Glutamine synthetase
Ligand
BDBM85291
Substrate
n/a
Meas. Tech.
Enzyme Assay
pH
7±0
Ki
0.47±0.12 nM
Citation
 Johnson, RC; Boettcher, BR; Cherpeck, RE; Dolson, MG Design and Synthesis of Potent Inhibitors of Glutamine Synthetase Bioorg Chem 18:154-9 (1990)   
Target
Name:
Glutamine synthetase
Synonyms:
GLNA_HUMAN | GLNS | GLUL | Glutamate decarboxylase
Type:
Protein
Mol. Mass.:
42066.51
Organism:
Homo sapiens (Human)
Description:
P15104
Residue:
373
Sequence:
MTTSASSHLNKGIKQVYMSLPQGEKVQAMYIWIDGTGEGLRCKTRTLDSEPKCVEELPEWNFDGSSTLQSEGSNSDMYLVPAAMFRDPFRKDPNKLVLCEVFKYNRRPAETNLRHTCKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADRAYGRDIVEAHYRACLYAGVKIAGTNAEVMPAQWEFQIGPCEGISMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKYIEEAIEKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRTVGQEKKGYFEDRRPSANCDPFSVTEALIRTCLLNETGDEPFQYKN
  
Inhibitor
Name:
BDBM85291
Synonyms:
Phosphinothricin analog, 4 (D,L Isomer)
Type:
Small organic molecule
Emp. Form.:
C7H13NO4P
Mol. Mass.:
206.1567
SMILES:
CP(O)([O-])C1=C[C@]([NH3+])(CC1)C([O-])=O |r,t:4|
Structure:
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