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Target
Kappa-type opioid receptor
Ligand
BDBM85395
Substrate
n/a
Ki
14±n/a nM
Comments
PDSP_1166
Citation
 McLaughlin, JP; Hill, KP; Jiang, Q; Sebastian, A; Archer, S; Bidlack, JM Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: in vivo and in vitro characterization of mu-selective agonist and antagonist activity. J Pharmacol Exp Ther 289:304-11 (1999) [PubMed] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | OPIATE Kappa | OPIATE Kappa 3 | OPRK1 | OPRK_BOVIN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42629.84
Organism:
CALF
Description:
Q2KIP6
Residue:
380
Sequence:
MEPPVQIFRGEPGPTCSPSTCLPPNGSGWFPGWAEPDGNGSAGSEDVLLEPAHISPVILVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKVVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWILSSSVGISAIVLGGTKVREDMEVIECSLQFPDDDYSWWDLFMKVCVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTAHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYVREVDGVNKPV
  
Inhibitor
Name:
BDBM85395
Synonyms:
MC-CAM
Type:
Small organic molecule
Emp. Form.:
C30H31ClN2O4
Mol. Mass.:
519.031
SMILES:
COc1ccc2CC3N(CC4CC4)CCC45[C@@H](Oc1c24)C(=O)CCC35NC(=O)\C=C/c1ccc(Cl)cc1 |r,TLB:25:24:19.5.6:8.14.13,9:8:24:19.5.6,THB:18:19:24:8.14.13|
Structure:
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