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Target
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Ligand
BDBM275885
Substrate
n/a
Meas. Tech.
Jump dilution assay
pH
7.5±n/a
Temperature
298.15±n/a K
Ki
19.0±2.7 nM
Comments
extracted
Citation
 Tonge, P; Pan, P Pyridone FabI inhibitors and uses thereof US Patent  US10071965 Publication Date 9/11/2018 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI
Synonyms:
Enoyl-ACP Reductase (FabI) | Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI | FABI_STAAR | NADPH-dependent enoyl-ACP reductase | fabI | trans-2-enoyl-[acyl carrier protein] reductase
Type:
Enzyme
Mol. Mass.:
27989.00
Organism:
Staphylococcus aureus
Description:
Q6GI75
Residue:
256
Sequence:
MLNLENKTYVIMGIANKRSIAFGVAKVLDQLGAKLVFTYRKERSRKELEKLLEQLNQPEAHLYQIDVQSDEEVINGFEQIGKDVGNIDGVYHSIAFANMEDLRGRFSETSREGFLLAQDISSYSLTIVAHEAKKLMPEGGSIVATTYLGGEFAVQNYNVMGVAKASLEANVKYLALDLGPDNIRVNAISAGPIRTLSAKGVGGFNTILKEIEERAPLKRNVDQVEVGKTAAYLLSDLSSGVTGENIHVDSGFHAIK
  
Inhibitor
Name:
BDBM275885
Synonyms:
US10071965, Compound PT179
Type:
Small organic molecule
Emp. Form.:
C14H15NO
Mol. Mass.:
213.275
SMILES:
CCc1ccn(Cc2ccccc2)c(=O)c1
Structure:
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