Ki Summary

Reaction Details

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Target

Somatostatin receptor type 3

Ligand

BDBM85080

Substrate

n/a

1000±n/a nM

Comments

PDSP_3367

Citation

Patel, YC Somatostatin and its receptor family. Front Neuroendocrinol 20:157-98 (1999) [PubMed] Article

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Target

Name:

Somatostatin receptor type 3

Synonyms:

SOMATOSTATIN SST3 | SS-3-R | SS3-R | SS3R | SSR-28 | SSR3_HUMAN | SSTR3 | Somatostatin receptor type 3 (SSTR3)

Type:

Protein

Mol. Mass.:

45855.97

Organism:

Homo sapiens (Human)

Description:

P32745

Residue:

418

Sequence:

MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL

Inhibitor

Name:

BDBM85080

Synonyms:

CH-275 | CH275 | L-Cys(1)-L-Lys-L-Phe-L-Phe-D-Trp-4-[(Isopropylamino)methyl]-L-Phe-L-Thr-L-Phe-L-Thr-L-Ser-L-Cys(1)-OH

Type:

Small organic molecule

Emp. Form.:

C74H96N14O15S2

Mol. Mass.:

1485.769

SMILES:

CC(C)NCc1ccc(C[C@H]2NC(=O)[C@H](Cc3c[nH]c4ccccc34)NC(=O)C(Cc3ccccc3)NC(=O)C(Cc3ccccc3)NC(=O)C(CCCCN)NC(=O)[C@H](N)CSSC[C@@H](NC(=O)[C@@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](Cc3ccccc3)NC(=O)C(NC2=O)C(C)O)C(C)O)C(O)=O)cc1

Structure: