Reaction Details Report a problem with these data
Target
Histamine H4 receptor
Ligand
BDBM50017657
Substrate
n/a
Ki
141.6±n/a nM
Comments
PDSP_521
Citation
 Nguyen, T; Shapiro, DA; George, SR; Setola, V; Lee, DK; Cheng, R; Rauser, L; Lee, SP; Lynch, KR; Roth, BL; O'Dowd, BF Discovery of a novel member of the histamine receptor family. Mol Pharmacol 59:427-33 (2001) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50017657
Synonyms:
1-(Diphenylmethyl)-4-(3-phenyl-2-propenyl)piperazine | 1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine | 1-Benzhydryl-4-cinnamylpiperazin | 1-Cinnamyl-4-(diphenylmethyl)piperazine | CHEMBL43064 | cid_1547484 | cinnarizine
Type:
Small organic molecule
Emp. Form.:
C26H28N2
Mol. Mass.:
368.5139
SMILES:
C(\C=C\c1ccccc1)N1CCN(CC1)C(c1ccccc1)c1ccccc1
Structure:
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