Reaction Details Report a problem with these data
Target
Tyrosinase
Ligand
BDBM50218209
Substrate
n/a
Meas. Tech.
Inhibition Assay
pH
6.8±0
Temperature
310.15±0 K
IC50
6.64e+3± 352.93 nM
Citation
 Khan, KM; Saify, ZS; Khan, MT; Butt, N; Maharvi, GM; Perveen, S; Ambreen, N; Choudhary, MI; Atta-Ur-Rahman, A; Supuran, CT Tyrosinase inhibition: conformational analysis based studies on molecular dynamics calculations of bipiperidine based inhibitors. J Enzyme Inhib Med Chem 20:401-7 (2005) [PubMed]  Article 
Target
Name:
Tyrosinase
Synonyms:
LB24-AB | Monophenol monooxygenase | SK29-AB | TYR | TYRO_HUMAN | Tumor rejection antigen AB
Type:
Protein
Mol. Mass.:
60388.08
Organism:
Homo sapiens (Human)
Description:
P14679
Residue:
529
Sequence:
MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLSGRGSCQNILLSNAPLGPQFPFTGVDDRESWPSVFYNRTCQCSGNFMGFNCGNCKFGFWGPNCTERRLLVRRNIFDLSAPEKDKFFAYLTLAKHTISSDYVIPIGTYGQMKNGSTPMFNDINIYDLFVWMHYYVSMDALLGGSEIWRDIDFAHEAPAFLPWHRLFLLRWEQEIQKLTGDENFTIPYWDWRDAEKCDICTDEYMGGQHPTNPNLLSPASFFSSWQIVCSRLEEYNSHQSLCNGTPEGPLRRNPGNHDKSRTPRLPSSADVEFCLSLTQYESGSMDKAANFSFRNTLEGFASPLTGIADASQSSMHNALHIYMNGTMSQVQGSANDPIFLLHHAFVDSIFEQWLRRHRPLQEVYPEANAPIGHNRESYMVPFIPLYRNGDFFISSKDLGYDYSYLQDSDPDSFQDYIKSYLEQASRIWSWLLGAAMVGAVLTALLAGLVSLLCRHKRKQLPEEKQPLLMEKEDYHSLYQSHL
  
Inhibitor
Name:
BDBM50218209
Synonyms:
CHEMBL250773 | Tyrosinase Inhibitor, 3 | naphthalen-2-yl(4-(piperidin-1-yl)piperidin-1-yl)methanone
Type:
Small organic molecule
Emp. Form.:
C21H26N2O
Mol. Mass.:
322.4439
SMILES:
O=C(N1CCC(CC1)N1CCCCC1)c1ccc2ccccc2c1
Structure:
Search PDB for entries with ligand similarity: