Reaction Details
Report a problem with these data
Report a problem with these dataTarget
Adenosine receptor A3
Ligand
BDBM21221
Substrate
n/a
Ki
14.89±n/a nM
Comments
PDSP_2051
Citation
Durand, IH; Green, RD Cloning of a chick A3 adenosine receptor: characterization of ligand binding and receptor-effector coupling of chick A1 and A3 adenosine receptors. Naunyn Schmiedebergs Arch Pharmacol 363:81-6 (2001) [PubMed] Article More Info.:
Target
Name:
Adenosine receptor A3
Synonyms:
ADENOSINE A3 | ADORA3
Type:
Enzyme Catalytic Domain
Mol. Mass.:
37723.59
Organism:
Chick
Description:
A0A8V1ACC1
Residue:
338
Sequence:
MCPQGSPCPASSSPINVTFNTSQVMGSIDVIYISAECLVALLAALGNIPVVWAVKLNAAFHNTTMYFIASLALADIAVGVFVVPLAVLVSLQVSIPFHFCLFLCCLMVVFTQASILSLLAIAIDRYLRVKLPIRYKIISTERRIWGALGLCWSLSLLVGLTPMFGWNKQRSAPYHTCGFTSVIRMDYMVYFSFFAWTLIPLSIMCALYVAVFYIIRTKLSQGATGARGAGTFYGKEFRKAKSLALILFLFAVSWLPLCIMNCVLYFHPEYKIPKPWIFLGILLSHANSAMNPVVYACKIKKFKTTYLLILRTYILCRKKPQAMPSSYRLNTPAVVDTE
Inhibitor
Name:
BDBM21221
Synonyms:
(2S,3S,4R,5R)-5-(2-chloro-6-{[(3-iodophenyl)methyl]amino}-9H-purin-9-yl)-3,4-dihydroxy-N-methyloxolane-2-carboxamide | 2-Cl-IB-MECA | 2-chloro-N6-(3-iodobenzyl)adenosine-5-N-methylcarboxamide | C-IBzA-MU | C1-IB-MECA | CHEMBL431733 | CI-IB-MECA | Cl-IB-MECA | US20230364057, Compound 76
Type:
Small organic molecule
Emp. Form.:
C18H18ClIN6O4
Mol. Mass.:
544.731
SMILES:
CNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NCc3cccc(I)c3)nc(Cl)nc12
Structure:
