Reaction Details Report a problem with these data
Target
Promotilin
Ligand
BDBM85993
Substrate
n/a
Ki
7.59±n/a nM
Comments
PDSP_6208
Citation
 Thielemans, L; Depoortere, I; Vanden Broeck, J; Peeters, TL The motilin pharmacophore in CHO cells expressing the human motilin receptor. Biochem Biophys Res Commun 293:1223-7 (2002) [PubMed]  Article 
Target
Name:
Promotilin
Synonyms:
MLN | MOTI_HUMAN | Motilin | Promotilin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12919.83
Organism:
Homo sapiens (Human)
Description:
Motilin 0 HUMAN::P12872
Residue:
115
Sequence:
MVSRKAVAALLVVHVAAMLASQTEAFVPIFTYGELQRMQEKERNKGQKKSLSVWQRSGEEGPVDPAEPIREEENEMIKLTAPLEIGMRMNSRQLEKYPATLEGLLSEMLPQHAAK
  
Inhibitor
Name:
BDBM85993
Synonyms:
Erythromycin-B enol ether
Type:
Small organic molecule
Emp. Form.:
C37H65NO11
Mol. Mass.:
699.9121
SMILES:
CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)C2(C)CC(C)=C(O2)[C@H](C)[C@@H](O)[C@H]1C |wU:23.24,25.25,8.8,30.34,21.22,12.12,18.18,27.28,47.51,2.1,wD:10.9,12.13,31.33,16.16,45.48,6.6,43.46,c:42,(3.08,2.25,;4.62,2.25,;5.39,.92,;6.93,.92,;7.7,2.25,;6.93,3.59,;9.24,2.25,;10.01,3.59,;10.01,.92,;11.55,.92,;12.32,2.25,;13.86,2.25,;14.63,3.59,;15.96,2.82,;15.96,4.36,;17.3,3.59,;13.86,4.92,;14.63,6.26,;12.32,4.92,;11.55,6.26,;11.55,3.59,;9.24,-.41,;7.91,.36,;10.01,-1.75,;11.55,-1.75,;12.32,-3.08,;11.55,-4.41,;12.32,-5.75,;11.55,-7.08,;13.86,-5.75,;14.63,-4.41,;13.86,-3.08,;14.63,-1.75,;16.17,-4.41,;16.94,-5.75,;16.94,-3.08,;9.24,-3.08,;10.73,-3.48,;8.84,-4.57,;6.72,-5.18,;5.95,-6.52,;5.39,-4.41,;6.82,-2.69,;4.62,-3.08,;3.08,-3.08,;5.39,-1.75,;6.93,-1.75,;4.62,-.41,;3.08,-.41,)|
Structure:
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