Reaction Details Report a problem with these data
Target
Glutathione S-transferase E2
Ligand
BDBM86110
Substrate
n/a
Meas. Tech.
GST Inhibition Assay
pH
6.5±0
Temperature
303.15±0 K
IC50
3.5e+3±n/a nM
Citation
 Muleya, V; Hayeshi, R; Ranson, H; Abegaz, B; Bezabih, MT; Robert, M; Ngadjui, BT; Ngandeu, F; Mukanganyama, S Modulation of Anopheles gambiae Epsilon glutathione transferase activity by plant natural products in vitro. J Enzyme Inhib Med Chem 23:391-9 (2008) [PubMed]  Article 
Target
Name:
Glutathione S-transferase E2
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
24847.25
Organism:
Anopheles gambiae (African malaria mosquito)
Description:
Q9GPL8
Residue:
221
Sequence:
MSNLVLYTLHLSPPCRAVELTAKALGLELEQKTINLLTGDHLKPEFVKLNPQHTIPVLDDNGTIITESHAIMIYLVTKYGKDDSLYPKDPVKQARVNSALHFESGVLFARMRFNFERILFFGKSDIPEDRVEYVQKSYELLEDTLVDDFVAGPTMTIADFSCISTISSIMGVVPLEQSKHPRIYAWIDRLKQLPYYEEANGGGGTDLGKFVLAKKEENAKA
  
Inhibitor
Name:
BDBM86110
Synonyms:
n/a
Type:
Small organic molecule
Emp. Form.:
C24H20O7
Mol. Mass.:
420.4114
SMILES:
COc1cc(O)c(c(O)c1C(C)=O)-c1c(C)cc(O)c2C(=O)c3c(O)cccc3Cc12 |(-3.58,-3.41,;-4.91,-2.64,;-4.91,-1.1,;-6.24,-.33,;-6.24,1.21,;-7.58,1.98,;-4.91,1.98,;-3.58,1.21,;-2.24,1.98,;-3.58,-.33,;-2.24,-1.1,;-.91,-.33,;-2.24,-2.64,;-4.91,3.52,;-3.58,4.29,;-2.24,3.52,;-3.58,5.83,;-4.91,6.6,;-4.91,8.14,;-6.24,5.83,;-7.58,6.6,;-7.58,8.14,;-8.91,5.83,;-10.24,6.6,;-10.24,8.14,;-11.58,5.83,;-11.58,4.29,;-10.24,3.52,;-8.91,4.29,;-7.58,3.52,;-6.24,4.29,)|
Structure:
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