Reaction Details Report a problem with these data
Target
Retinol-binding protein 4
Ligand
BDBM249490
Substrate
n/a
Meas. Tech.
TR-FRET Assay for Retinol-induced RBP4-TTR Interaction
pH
7.5±n/a
IC50
14.7±n/a nM
Comments
extracted
Citation
 Petrukhin, K; Cioffi, C; Johnson, G; Allikmets, R; Freeman, E; Chen, P; Conlon, M; Zhu, L Substituted 4-phenylpiperidines, their preparation and use US Patent  US10072016 Publication Date 9/11/2018 
Target
Name:
Retinol-binding protein 4
Synonyms:
PRBP | Plasma retinol-binding protein | RBP | RBP4 | RET4_HUMAN | Retinol-binding protein 4 | Retinol-binding protein 4 (RBP4) | spa binding assay for rbp4
Type:
Protein
Mol. Mass.:
23008.75
Organism:
Homo sapiens (Human)
Description:
P02753
Residue:
201
Sequence:
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
  
Inhibitor
Name:
BDBM249490
Synonyms:
US10072016, Compound 88 | US10407433, Compound 88 | US10913746, Compound 88 | US11649240, Compound 88 | US9434727, 88 | US9777010, Compound 88
Type:
Small organic molecule
Emp. Form.:
C23H25F5N4O
Mol. Mass.:
468.4628
SMILES:
Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CCN(CC4CC4)Cc23)c(c1F)C(F)(F)F
Structure:
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