Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM86263
Substrate
n/a
Ki
1100±n/a nM
Comments
PDSP_6976
Citation
 Bramlett, KS; Houck, KA; Borchert, KM; Dowless, MS; Kulanthaivel, P; Zhang, Y; Beyer, TP; Schmidt, R; Thomas, JS; Michael, LF; Barr, R; Montrose, C; Eacho, PI; Cao, G; Burris, TP A natural product ligand of the oxysterol receptor, liver X receptor. J Pharmacol Exp Ther 307:291-6 (2003) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM86263
Synonyms:
CAS_57186-25-1 | NSC_0 | paxilline
Type:
Small organic molecule
Emp. Form.:
C27H33NO4
Mol. Mass.:
435.5552
SMILES:
CC(C)(O)C1OC2CCC3(C)C4(C)C(Cc5c4[nH]c4ccccc54)CCC3(O)C2=CC1=O |c:33|
Structure:
Search PDB for entries with ligand similarity: