Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM76171
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
4823±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM76171
Synonyms:
(2E,6E)-2,6-bis(3-chloro-5-ethoxy-4-hydroxy-benzylidene)cyclohexanone | (2E,6E)-2,6-bis[(3-chloranyl-5-ethoxy-4-oxidanyl-phenyl)methylidene]cyclohexan-1-one | (2E,6E)-2,6-bis[(3-chloro-5-ethoxy-4-hydroxyphenyl)methylidene]-1-cyclohexanone | (2E,6E)-2,6-bis[(3-chloro-5-ethoxy-4-hydroxyphenyl)methylidene]cyclohexan-1-one | 2,6-bis(3-chloro-5-ethoxy-4-hydroxybenzylidene)cyclohexanone | MLS000540055 | SMR000162201 | cid_1751796
Type:
Small organic molecule
Emp. Form.:
C24H24Cl2O5
Mol. Mass.:
463.35
SMILES:
CCOc1cc(\C=C2/CCC\C(=C/c3cc(Cl)c(O)c(OCC)c3)C2=O)cc(Cl)c1O
Structure:
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