Reaction Details Report a problem with these data
Target
Tegument protein VP16
Ligand
BDBM68079
Substrate
n/a
Meas. Tech.
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3)
IC50
4069±n/a nM
Citation
 PubChem, PC Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) PubChem Bioassay (2012)[AID] 
Target
Name:
Tegument protein VP16
Synonyms:
Alpha trans-inducing protein (VP16) | VP16_HHV11 | transactivating tegument protein VP16
Type:
PROTEIN
Mol. Mass.:
54325.13
Organism:
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus1)
Description:
EBI_100271
Residue:
490
Sequence:
MDLLVDELFADMNADGASPPPPRPAGGPKNTPAAPPLYATGRLSQAQLMPSPPMPVPPAALFNRLLDDLGFSAGPALCTMLDTWNEDLFSALPTNADLYRECKFLSTLPSDVVEWGDAYVPERTQIDIRAHGDVAFPTLPATRDGLGLYYEALSRFFHAELRAREESYRTVLANFCSALYRYLRASVRQLHRQAHMRGRDRDLGEMLRATIADRYYRETARLARVLFLHLYLFLTREILWAAYAEQMMRPDLFDCLCCDLESWRQLAGLFQPFMFVNGALTVRGVPIEARRLRELNHIREHLNLPLVRSAATEEPGAPLTTPPTLHGNQARASGYFMVLIRAKLDSYSSFTTSPSEAVMREHAYSRARTKNNYGSTIEGLLDLPDDDAPEEAGLAAPRLSFLPAGHTRRLSTAPPTDVSLGDELHLDGEDVAMAHADALDDFDLDMLGDGDSPGPGFTPHDSAPYGALDMADFEFEQMFTDALGIDEYGG
  
Inhibitor
Name:
BDBM68079
Synonyms:
3,5,6-trichloro-1-(4-methylphenyl)-2(1H)-pyrazinone | 3,5,6-trichloro-1-(4-methylphenyl)-2-pyrazinone | 3,5,6-trichloro-1-(4-methylphenyl)pyrazin-2-one | 3,5,6-trichloro-1-(p-tolyl)pyrazin-2-one | 3,5,6-tris(chloranyl)-1-(4-methylphenyl)pyrazin-2-one | MLS000702799 | SMR000229702 | cid_849396
Type:
Small organic molecule
Emp. Form.:
C11H7Cl3N2O
Mol. Mass.:
289.545
SMILES:
Cc1ccc(cc1)-n1c(Cl)c(Cl)nc(Cl)c1=O
Structure:
Search PDB for entries with ligand similarity: