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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM51055
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
7660±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM51055
Synonyms:
(E)-2-cyano-N-(2-methoxyphenyl)-3-(5-nitro-2-pyrrolidin-1-yl-phenyl)prop-2-enamide | (E)-2-cyano-N-(2-methoxyphenyl)-3-(5-nitro-2-pyrrolidin-1-ylphenyl)prop-2-enamide | (E)-2-cyano-N-(2-methoxyphenyl)-3-(5-nitro-2-pyrrolidino-phenyl)acrylamide | (E)-2-cyano-N-(2-methoxyphenyl)-3-[5-nitro-2-(1-pyrrolidinyl)phenyl]-2-propenamide | MLS000409077 | SMR000264073 | cid_5917350
Type:
Small organic molecule
Emp. Form.:
C21H20N4O4
Mol. Mass.:
392.4079
SMILES:
COc1ccccc1NC(=O)C(=C\c1cc(ccc1N1CCCC1)[N+]([O-])=O)\C#N
Structure:
Search PDB for entries with ligand similarity: