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Target
Corticotropin-releasing factor-binding protein
Ligand
BDBM91323
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex
EC50
>53000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex PubChem Bioassay (2012)[AID] 
Target
Name:
Corticotropin-releasing factor-binding protein
Synonyms:
CRFBP | CRHBP | CRHBP_HUMAN | corticotropin releasing factor-binding protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
36143.95
Organism:
Homo sapiens (Human)
Description:
P24387
Residue:
322
Sequence:
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
  
Inhibitor
Name:
BDBM91323
Synonyms:
4-(6-chloranylpyridin-3-yl)sulfonyl-2-methyl-1-(3-methylphenyl)piperazine | 4-(6-chloropyridin-3-yl)sulfonyl-2-methyl-1-(3-methylphenyl)piperazine | 4-[(6-chloro-3-pyridinyl)sulfonyl]-2-methyl-1-(3-methylphenyl)piperazine | 4-[(6-chloro-3-pyridyl)sulfonyl]-2-methyl-1-(m-tolyl)piperazine | MLS002251814 | SMR001314189 | cid_4883321
Type:
Small organic molecule
Emp. Form.:
C17H20ClN3O2S
Mol. Mass.:
365.878
SMILES:
CC1CN(CCN1c1cccc(C)c1)S(=O)(=O)c1ccc(Cl)nc1
Structure:
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