Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM76188
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2
Temperature
298.15±n/a K
IC50
13100±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM76188
Synonyms:
1-methyl-5-methylsulfonyl-3-nitro-1,2,4-triazole | 5-mesyl-1-methyl-3-nitro-1,2,4-triazole | MLS000678365 | SMR000285230 | cid_3148843
Type:
Small organic molecule
Emp. Form.:
C4H6N4O4S
Mol. Mass.:
206.18
SMILES:
Cn1nc(nc1S(C)(=O)=O)[N+]([O-])=O
Structure:
