Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM59063
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM59063
Synonyms:
4-butyl-1-sulfanylidene-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one | 4-butyl-1-thioxo-2H-[1,2,4]triazolo[4,3-a]quinazolin-5-one | MLS001172798 | SMR000595763 | US20230365568, Compound 23 | cid_2120114
Type:
Small organic molecule
Emp. Form.:
C13H14N4OS
Mol. Mass.:
274.341
SMILES:
CCCCn1c2n[nH]c(=S)n2c2ccccc2c1=O
Structure:
