Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM91534
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2
Temperature
298.15±n/a K
IC50
>99000±n/a nM
Comments
extracted
Citation
PubChem, PC SAR analysis of small molecule inhibitors of APOBEC3A DNA Deaminase via a fluorescence-based single-stranded DNA deaminase assay - Set 2 PubChem Bioassay (2012)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM91534
Synonyms:
7-(2-thienyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid | 7-thiophen-2-yl-2-pyrazolo[1,5-a]pyrimidinecarboxylic acid | 7-thiophen-2-ylpyrazolo[1,5-a]pyrimidine-2-carboxylic acid | MLS-0471589.0001 | cid_6485368
Type:
Small organic molecule
Emp. Form.:
C11H7N3O2S
Mol. Mass.:
245.257
SMILES:
OC(=O)c1cc2nccc(-c3cccs3)n2n1
Structure:
