Reaction Details Report a problem with these data
Target
Dual specificity mitogen-activated protein kinase kinase 6
Ligand
BDBM29678
Substrate
n/a
Meas. Tech.
Fluorescence Polarization (FP) Assay
IC50
>2.50e+5±n/a nM
Citation
 Bannwarth, L; Goldberg, AB; Chen, C; Turk, BE Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening. Chem Biol 19:875-82 (2012) [PubMed]  Article 
Target
Name:
Dual specificity mitogen-activated protein kinase kinase 6
Synonyms:
Dual specificity mitogen-activated protein kinase kinase 6 | MAP kinase kinase 6 | MAP2K6 | MAPK/ERK kinase 6 | MAPKK 6 | MEK6 | MKK6 | MP2K6_HUMAN | Mitogen-activated protein kinase kinase 6 (MKK6) | PRKMK6 | SAPKK3 | SKK3
Type:
Protein
Mol. Mass.:
37494.96
Organism:
Homo sapiens (Human)
Description:
P52564
Residue:
334
Sequence:
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHESKGTDVASFVKLILGD
  
Inhibitor
Name:
BDBM29678
Synonyms:
Reduced parellic acid, 9
Type:
Small organic molecule
Emp. Form.:
C18H16O8
Mol. Mass.:
360.3148
SMILES:
COc1cc(C(O)=O)c2Oc3c(CO)c(O)cc(C)c3C(=O)Oc2c1C
Structure:
Search PDB for entries with ligand similarity: