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Target
Pancreatic alpha-amylase
Ligand
BDBM92365
Substrate
n/a
Meas. Tech.
Enzymatic Activity Assay
pH
7±0
Temperature
310.15±0 K
Ki
2.34e+5± 6.1e+4 nM
IC50
1.25e+5± 1.8e+3 nM
Citation
 Senger, MR; Gomes, Lda C; Ferreira, SB; Kaiser, CR; Ferreira, VF; Silva, FP Kinetics Studies on the Inhibition Mechanism of Pancreatic α-Amylase by Glycoconjugated 1H-1,2,3-Triazoles: A New Class of Inhibitors with Hypoglycemiant Activity. Chembiochem 13:1584-93 (2012) [PubMed]  Article 
Target
Name:
Pancreatic alpha-amylase
Synonyms:
1,4-alpha-D-glucan glucanohydrolase | AMY2 | AMYP_PIG | Pancreatic α-amylase | Pancreatic α-amylase
Type:
Protein
Mol. Mass.:
57088.07
Organism:
Sus scrofa (Pig)
Description:
P00690
Residue:
511
Sequence:
MKLFLLLSAFGFCWAQYAPQTQSGRTSIVHLFEWRWVDIALECERYLGPKGFGGVQVSPPNENIVVTNPSRPWWERYQPVSYKLCTRSGNENEFRDMVTRCNNVGVRIYVDAVINHMCGSGAAAGTGTTCGSYCNPGNREFPAVPYSAWDFNDGKCKTASGGIESYNDPYQVRDCQLVGLLDLALEKDYVRSMIADYLNKLIDIGVAGFRIDASKHMWPGDIKAVLDKLHNLNTNWFPAGSRPFIFQEVIDLGGEAIQSSEYFGNGRVTEFKYGAKLGTVVRKWSGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKVAVGFMLAHPYGFTRVMSSYRWARNFVNGQDVNDWIGPPNNNGVIKEVTINADTTCGNDWVCEHRWRQIRNMVWFRNVVDGQPFANWWANGSNQVAFGRGNRGFIVFNNDDWQLSSTLQTGLPGGTYCDVISGDKVGNSCTGIKVYVSSDGTAQFSISNSAEDPFIAIHAESKL
  
Inhibitor
Name:
BDBM92365
Synonyms:
GPESB11
Type:
Small organic molecule
Emp. Form.:
C14H21N3O6
Mol. Mass.:
327.333
SMILES:
CO[C@@H]1O[C@H](Cn2cc(COC(C)=O)nn2)[C@@H]2OC(C)(C)OC12 |r|
Structure:
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