Reaction Details Report a problem with these data
Target
Protein RecA
Ligand
BDBM92391
Substrate
n/a
Meas. Tech.
Fluorescent Reporter Assay
IC50
7.7e+4±n/a nM
Citation
 Zhang, L; Zheng, Y; Callahan, B; Belfort, M; Liu, Y Cisplatin inhibits protein splicing, suggesting inteins as therapeutic targets in mycobacteria. J Biol Chem 286:1277-82 (2011) [PubMed]  Article 
Target
Name:
Protein RecA
Synonyms:
RECA_ECOLI | lexB | recA | recH | rnmB | tif | umuB | zab
Type:
Protein
Mol. Mass.:
37964.88
Organism:
Escherichia coli
Description:
C6EJT2
Residue:
353
Sequence:
MAIDENKQKALAAALGQIEKQFGKGSIMRLGEDRSMDVETISTGSLSLDIALGAGGLPMGRIVEIYGPESSGKTTLTLQVIAAAQREGKTCAFIDAEHALDPIYARKLGVDIDNLLCSQPDTGEQALEICDALARSGAVDVIVVDSVAALTPKAEIEGEIGDSHMGLAARMMSQAMRKLAGNLKQSNTLLIFINQIRMKIGVMFGNPETTTGGNALKFYASVRLDIRRIGAVKEGENVVGSETRVKVVKNKIAAPFKQAEFQILYGEGINFYGELVDLGVKEKLIEKAGAWYSYKGEKIGQGKANATAWLKDNPETAKEIEKKVRELLLSNPNSTPDFSVDDSEGVAETNEDF
  
Inhibitor
Name:
BDBM92391
Synonyms:
Pt(NH3)2(im)Cl, 6
Type:
Small organic molecule
Emp. Form.:
C3H10ClN4Pt
Mol. Mass.:
332.674
SMILES:
[NH3+][Pt]([NH3+])(Cl)[n+]1cc[nH]c1
Structure:
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