Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM50018731
Substrate
n/a
Ki
157±n/a nM
Comments
PDSP_601
Citation
 Mogil, JS; Pasternak, GW The molecular and behavioral pharmacology of the orphanin FQ/nociceptin peptide and receptor family. Pharmacol Rev 53:381-415 (2001) [PubMed] 
Target
Name:
Nociceptin receptor
Synonyms:
K3 opiate receptor | KOR-3 | Kappa-type 3 opioid receptor | Nociceptin receptor | Nociceptin/Orphanin FQ, NOP receptor | OPRX_MOUSE | ORGC | Oor | Oprl | Oprl1 | Orphanin FQ receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40499.09
Organism:
MOUSE
Description:
Nociceptin/Orphanin FQ, NOP receptor 0 MOUSE::P35377
Residue:
367
Sequence:
MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
  
Inhibitor
Name:
BDBM50018731
Synonyms:
(Cyclazocine) 3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol | (cyclazocine)2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid | 10-cyclopropylmethyl-1,13-dimethyl-10-azatricyclo[7.3.1.02,7]trideca-2(7),3,5-trien-4-ol(Cyclazocine) | 3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol (cyclazocine) | 3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol(Cyclazocine) | 3-cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexahydro-2,6-methano-benzo[d]azocin-8-ol | CYCLAZOCINE (-) | Cyclazocine (+)
Type:
Small organic molecule
Emp. Form.:
C18H25NO
Mol. Mass.:
271.3972
SMILES:
CC1C2Cc3ccc(O)cc3C1(C)CCN2CC1CC1 |TLB:16:15:1:3.4.10|
Structure:
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