Reaction Details Report a problem with these data
Target
Isochorismatase family protein
Ligand
BDBM50026863
Substrate
n/a
Meas. Tech.
GDH-Coupled Nicotinamidase Assay
Ki
11±1 nM
Citation
 French, JB; Cen, Y; Vrablik, TL; Xu, P; Allen, E; Hanna-Rose, W; Sauve, AA Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism. Biochemistry 49:10421-39 (2010) [PubMed]  Article 
Target
Name:
Isochorismatase family protein
Synonyms:
Nicotinamidase (SpNic) | Pyrazinamidase/nicotinamidase
Type:
Enzyme
Mol. Mass.:
21361.69
Organism:
Streptococcus pneumoniae
Description:
A0A098ZGI7
Residue:
191
Sequence:
MTKALISIDYTEDFVADSGKLTAGAPAQAISDAISKVTRLAFERGDYIFFTIDAHEENDCFHPESKLFPPHNLIGTSGRNLYGDLGIFYQEHGSDSRVFWMDKRHYSAFSGTDLDIRLRERRVSTVILTGVLTDICVLHTAIDAYNLGYDIEIVKPAVASIWPENHQFALGHFKNTLGAKLVDENLNELSE
  
Inhibitor
Name:
BDBM50026863
Synonyms:
CHEMBL268493 | Nicotinamidase Inhibitor, 16 | PncA Inhibitor, 2 | Pyridine-3-carbaldehyde
Type:
Small organic molecule
Emp. Form.:
C6H5NO
Mol. Mass.:
107.11
SMILES:
O=Cc1cccnc1
Structure:
Search PDB for entries with ligand similarity: