Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM92894
Substrate
n/a
Meas. Tech.
Competitive Inhibition Assay
Ki
500±100 nM
Citation
 Dahl, G; Arenas, OG; Danielson, UH Hepatitis C virus NS3 protease is activated by low concentrations of protease inhibitors. Biochemistry 48:11592-602 (2009) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
NS3 protein
Type:
Protein
Mol. Mass.:
45665.89
Organism:
Hepatitis C virus
Description:
Q04045
Residue:
428
Sequence:
VFTDNSSPPAVPQSFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAATLGFGAYMSKAHGVDPNIRTGVRTITTGSPITYSTYGKFLADGGCSGGAYDIIICDECHSTDATSILGIGTVLDQAETAGARLVVLATATPPGSVTVSHPNIEEVALSTTGEIPFYGKAIPLEVIKGGRHLIFCHSKKKCDELAAKLVALGINAVAYYRGLDVSVIPTSGDVVVVSTDALMTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRTQRRGRTGRGKPGIYRFVAPGERPSGMFDSSVLCECYDAGCAWYELTPAETTVRLRAYMNTPGLPVCQDHLEFWEGVFTGLTHIDAHFLSQTKQSGENFPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHGPTPLLYRLGAVQNEVT
  
Inhibitor
Name:
BDBM92894
Synonyms:
NS3 Protease Inhibitor, 5
Type:
Small molecule
Emp. Form.:
C31H40N4O8S
Mol. Mass.:
628.736
SMILES:
CC(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccc2ccccc2c1)C(=O)N[C@@H](CS)C(O)=O |r|
Structure:
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